Volume 23, Number 4 (12-2015)                   Sci J Hamadan Nurs Midwifery Fac 2015, 23(4): 22-28 | Back to browse issues page


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Alimohammadi S, Kazemi F, Zamani M, Rahmani Z, Masoumi S Z. The relationship between maternal serum level of alpha-fetoprotein in weeks 11 to 13 of pregnancy and preterm labor. Sci J Hamadan Nurs Midwifery Fac. 2015; 23 (4) :22-28
URL: http://nmj.umsha.ac.ir/article-1-1440-en.html

1- , mehrangiz.zamani@yahoo.com
Abstract:   (2662 Views)

Background: Preterm labor is considered one of the major health concerns and seconds congenital anomalies for infant morbidity and mortality. So far, various methods have been used to predict preterm labor; one of these methods is to measure mother’s serum alpha-fetoprotein level. This study was conducted to investigate the relationship between maternal serum alpha-fetoprotein level in weeks 11 to 13 of pregnancy and preterm labor.

Methods: This nested case-control study was conducted with 105 pregnant women during their 11-13 gestation week presenting to Fatemieh Hospital in Hamedan for their routine prenatal care from 2013 to 2014. Maternal serum alpha-fetoprotein level was measured by Biomerieux standard kits through Vidas system in laboratory. Pregnancy outcomes were followed up after delivery and recorded in a checklist. The data were entered into SPSS/21 software and were analyzed using the t-test, Mann-Whitney U test and Chi-square test. P-value less than 0.05 was considered significant.

Results: Maternal serum alpha-fetoprotein level at 11-13 weeks was significantly higher in pregnant women experiencing preterm labor than that in women with term pregnancy (P<0.001).

Conclusion: Maternal serum alpha-fetoprotein level in 11-13 weeks of pregnancy can help predict preterm labor in pregnant women.

Full-Text [PDF 613 kb]   (650 Downloads)    
Type of Study: Research | Subject: Midwifery
Received: 2015/10/31 | Accepted: 2015/12/22 | Published: 2016/03/6

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