Volume 25, Issue 4 (11-2017)                   Avicenna J Nurs Midwifery Care 2017, 25(4): 147-153 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zarei M, Mohammadi P, Beygvand P, Fereydouni M A, Roshanaei G, Hajilooei M et al . The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women. Avicenna J Nurs Midwifery Care 2017; 25 (4) :147-153
URL: http://nmj.umsha.ac.ir/article-1-1734-en.html
1- Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
3- Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (8149 Views)

Background: Blood pressure increases in women after menopause. There is evidences that support the existence of the increased reactive oxygen species levels in hypertension. The glutathione has an important role in cell defense against oxidative stress.The aim of this study was comprising of serum glutathione level between hypertensive and normotensive postmenopausal women.

Methods: This research was a case-control study. The samples were selected among patients who had the inclusion criteria. Samples were 39 postmenopausal women with high blood pressure as case group and the control group was chosen among 40 postmenopausal women with normal blood pressure. After filling in the testimonial and the checklist, blood samples were taken for test subjects. Then the glutathione blood levels were measured using the kit and ELISA. Data were analyzed by t- test, F-test and the non-parametric Mann-Whitney test at a significant level of 5 percent.

Results: There was a significant difference between mean systolic and diastolic blood pressure (P= 0.029 & P= 0.047, respectively), serum glutathione level (P= 0.045), body mass index (P= 0.041), and weekly exercise less than 30 minutes (P= 0.049) in postmenopausal women with high blood pressure and normal blood pressure. However, no significant differences in age of onset of menopause, the number of children, employment status, and daily consumption of dairy products was observed between the two groups.

Conclusion: The results of this study showed that the serum glutathione levels in postmenopausal women with high blood pressure were lower than normal menopausal women.

Persian Full-Text [PDF 254 kb]   (1379 Downloads)    
Type of Study: case report | Subject: Nursing
Received: 2017/05/26 | Accepted: 2017/07/6 | Published: 2017/07/17

References
1. Cunha RM, Vilaça-Alves J, Noleto MV, Silva JS, Costa AM, Silva CNF, et al. Acute blood pressure response in hypertensive elderly women immediately after water aerobics exercise: A crossover study. Clinical and Experimental Hypertension. 2017:1-6. https://doi.org/10.1080/10641963.2016.1226891
2. Kim M-J, Cho J, Ahn Y, Yim G, Park H-Y. Association between physical activity and menopausal symptoms in perimenopausal women. BMC women's health. 2014;14(1):122. [DOI] [PubMed]
3. Ong KL, Tso AW, Lam KS, Cheung BM. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008;51(4):1142-8. [DOI] [PubMed]
4. Somani Y, Baross A, Levy P, Zinszer K, Milne K, Swaine I, et al. Reductions in ambulatory blood pressure in young normotensive men and women after isometric resistance training and its relationship with cardiovascular reactivity. Blood pressure monitoring. 2017;22(1):1-7. [DOI] [PubMed]
5. Reckelhoff JF, Fortepiani LA. Novel mechanisms responsible for postmenopausal hypertension. Hypertension. 2004;43(5):918-23. [DOI] [PubMed]
6. Redón J, Oliva MR, Tormos C, Giner V, Chaves J, Iradi A, et al. Antioxidant activities and oxidative stress by products in human hypertension. Hypertension. 2003;41(5):1096-101. [DOI] [PubMed]
7. Wassertheil-Smoller S, Anderson G, Psaty BM, Black HR, Manson J, Wong N, et al. Hypertension and its treatment in postmenopausal women. Hypertension. 2000;36(5):780-9. [DOI] [PubMed]
8. Yanes LL, Reckelhoff JF. Postmenopausal hypertension. American journal of hypertension. 2011;24(7). [DOI] [PubMed]
9. Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Biochimica et Biophysica Acta (BBA)-General Subjects. 2013;1830(5):3289-303. [DOI] [PubMed]
10. Barranco-Ruiz Y, Aragón-Vela J, Casals C, Martínez-Amat A, Casuso RA, Huertas JR. Control of antioxidant supplementation through interview is not appropriate in oxidative-stress sport studies: Analytical confirmation should be required. Nutrition. 2017;33:278-84. [DOI] [PubMed]
11. Lu SC. Glutathione synthesis. Biochimica et Biophysica Acta (BBA)-General Subjects. 2013;1830(5):3143-53. [DOI] [PubMed]
12. Aquilano K, Baldelli S, Ciriolo MR. Glutathione: new roles in redox signaling for an old antioxidant. 2014.
13. Ribas V, García-Ruiz C, Fernández-Checa JC. Glutathione and mitochondria. 2014.
14. Harshbarger W, Gondi S, Ficarro SB, Hunter J, Udayakumar D, Gurbani D, et al. Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. Journal of Biological Chemistry. 2017;292(1):112-20. [DOI] [PubMed]
15. Freed R, Hollenhorst C, Mao X, Weiduschat N, Shungu D, Gabbay V. 946-Decreased Occipital Glutathione in Adolescent Depression: A Magnetic Resonance Spectroscopy Study. Biological Psychiatry. 2017;81(10):S383. [DOI]
16. Oelze M, Kröller-Schön S, Steven S, Lubos E, Doppler C, Hausding M, et al. Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in AgingNovelty and Significance. Hypertension. 2014;63(2):390-6. [DOI] [PubMed]
17. Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S. The Global Burden of Disease Study 2015 and Blood Pressure. Taylor & Francis; 2017.
18. Polimanti R, Piacentini S, Lazzarin N, Re MA, Manfellotto D, Fuciarelli M. Glutathione S-transferase variants as risk factor for essential hypertension in Italian patients. Molecular and cellular biochemistry. 2011;357(1-2):227-33. [DOI] [PubMed]
19. Salini A, Jeyanthi GP. Impact of Estradiol on Circulating Markers of Oxidative Stress among Hypertensive Postmenopausal Women with Co-morbidities. International Journal of Medical Research and Review. 2014;2(06).
20. Farzanegi P, Habibian M, Delavari H. The effect of aerobic exercise on the levels of vascular endothelial growth factor and glucose in hypertensive postmenopausal women: A randomized clinical trial. Qom Univ Med Sci J. 2014;8(4):6-12.
21. Seifi-Skishahr F, Damirchi A, Farjaminezhad M, Babaei P. The Comparison of One-Session Intensive Aerobic Exercise Effects on Glutathione Redox State of Red Blood Cells in Professional, Recreational Athletes and Nonathletes.
22. El Khoudary SR, Shields KJ, Janssen I, Budoff MJ, Everson‐Rose SA, Powell LH, Matthews KA. Postmenopausal Women With Greater Paracardial Fat Have More Coronary Artery Calcification Than Premenopausal Women: The Study of Women9s Health Across the Nation (SWAN) Cardiovascular Fat Ancillary Study. Journal of the American Heart Association. 2017 Feb 1;6(2):e004545
23. Choi I-Y, Lee P, Denney DR, Spaeth K, Nast O, Ptomey L, et al. Dairy intake is associated with brain glutathione concentration in older adults. The American journal of clinical nutrition. 2015;101(2):287-93. [DOI] [PubMed]

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Avicenna Journal of Nursing and Midwifery Care

Designed & Developed by : Yektaweb