Background: According to the world health organization report, mental disorders are major causes of morbidity and disability in the world and can reduce one’s success and progress in his life. The aim of this study was to c o mpare general health in treatment -seeking drug-dependent men and women in Hamadan, Iran. 

  Methods: This comparative cross-sectional study was done on 119 participants (59 women and 60 men) selected by available sampling. Data collection instrument was Goldberg's 28-item general health questionnaire. Data was analyzed by descriptive and inferential statistics.

  Results: Results of the study showed that 53.33% of subjects had some problems in general health Indexes. Assessing the results of the groups separately, demonstrated that 66.87% of males and 59.73% of females were not in good general health. Comparing the results showed a statistically meaningful difference between two groups (P<0.05).

  Conclusion: Findings of this study showed that disorders related to general health
is prevalent among treatment -seeking drug-dependents. To prevent from spreading the idea that addiction treatment centers are not efficient and also to prevent from drug-dependents’ disappointment from referring to these centers, it is needed to pay attention to their general health along with the treatments they receive for addiction.