%0 Journal Article %A Alimohammadi, Shohreh %A Kazemi, Farideh %A Zamani, Mehrangiz %A Rahmani, Zohreh %A Masoumi, Seyedeh Zahra %T The relationship between maternal serum level of alpha-fetoprotein in weeks 11 to 13 of pregnancy and preterm labor %J Avicenna Journal of Nursing and Midwifery Care %V 23 %N 4 %U http://nmj.umsha.ac.ir/article-1-1440-en.html %R %D 2015 %K Alpha-Fetoprotein, Pregnancy, Preterm Labor, %X Background: Preterm labor is considered one of the major health concerns and seconds congenital anomalies for infant morbidity and mortality. So far, various methods have been used to predict preterm labor; one of these methods is to measure mother’s serum alpha-fetoprotein level. This study was conducted to investigate the relationship between maternal serum alpha-fetoprotein level in weeks 11 to 13 of pregnancy and preterm labor. Methods: This nested case-control study was conducted with 105 pregnant women during their 11-13 gestation week presenting to Fatemieh Hospital in Hamedan for their routine prenatal care from 2013 to 2014. Maternal serum alpha-fetoprotein level was measured by Biomerieux standard kits through Vidas system in laboratory. Pregnancy outcomes were followed up after delivery and recorded in a checklist. The data were entered into SPSS/21 software and were analyzed using the t-test, Mann-Whitney U test and Chi-square test. P-value less than 0.05 was considered significant. Results: Maternal serum alpha-fetoprotein level at 11-13 weeks was significantly higher in pregnant women experiencing preterm labor than that in women with term pregnancy (P<0.001). Conclusion: Maternal serum alpha-fetoprotein level in 11-13 weeks of pregnancy can help predict preterm labor in pregnant women. %> http://nmj.umsha.ac.ir/article-1-1440-en.pdf %P 22-28 %& 22 %! %9 Original Research %L A-10-80-3 %+ %G eng %@ 2676-5748 %[ 2015