Background: Nurses’ Job satisfaction and burnout are two important components of health care organizations. Nurses are the majority of hospital personnel so these two important organizational variables have a direct relation to quality of nursing services and community health and also have crucial role in organizational goal achievement.

Method: This is an analytic-descriptive study which was done in 2015 on 299 nurses who worked in Hamadan educational and treatment centers. They were selected based on stratified proportional random sampling. Data were collected by Minnesota job satisfaction and Maslach's burnout questionnaires. Using descriptive statistics and inferential statistics (Pearson Correlation Coefficient and Stepwise Multiple Regression) data were analyzed by SPSS 16 software.

Results: Findings showed that nurses regarding their job satisfaction were moderately satisfied  and had low level of  burnout. There was a significant and negative correlation between nurses' job satisfaction and emotional exhaustion      (r=-.664, p<0.01). There was a significant and positive correlation between nurses' job satisfaction and personal accomplishment (r=.449, p<0.01). There was a significant and negative correlation between nurses' job satisfaction and depersonalization (r=-.503, p<0.01). Job satisfaction dimensions such as extrinsic and intrinsic satisfaction predicted ( 44% and 20%) of variance in emotional exhaustion and personal accomplishment respectively. Intrinsic satisfaction  predicted ( 26%) of variance in  depersonalization as well  .

Conclusion: job satisfaction dimensions were significant predictors of nurses' burnout. So, paying more attention to factors that increase job satisfaction by health system policy-makers can decrease nurses' burnout.

Key words: job satisfaction, burnout, nurses