Background: The clinical decision-making is a process of critical thinking to choose the best practice to achieve the desired objectives. Nurses in the health system known as one of the important health service providers that clinical decision-making is one of their duties in the field. Therefore, they should have the ability to make appropriate clinical decisions. This study was conducted to assess the relationship between self-efficacy and clinical decision-making of nurses working in hospitals in Bushehr in 2015.

Methods: This was a descriptive analytic study, which have been done cross section on the 247 nurses working in hospitals in Bushehr that were selected by stratified random sampling method. Schwartz & Jerusalem General Self-Efficacy Questionnaire and Jenkins clinical decision questionnaire were used as data collection tools. Data were analyzed by SPSS/22.

Results: The study findings showed that the nurses have been in good condition in term of self-efficacy (21.33) and clinical decision-making (45.61). There were significant relationship between clinical decision-making with age (r=0.198, p<0.01), working experience (r=0.203, p<0.01), and gender of nurses (chi=56.532, p<0.05). Finally, a significant, positive and relatively strong relationship was identified between nurses self-efficacy and their clinical decision-making ability in this study (r=0.563, p<0.01).

Conclusion: Based on the importance of clinical decision-making for nurse and its significant relationship with their self-efficacy and the effect of both of them on performance improvements, Recommended in the policy-making process to improve the quantity and quality of services, improving of the self- efficacy and clinical decision-making of nurses should be considered in the health system.