Appropriate adaptation with the multiple sclerosis can help to reduce problems. One of the more effective and practical templates in nursing has more attentive to this topic is Roy Adaptation model. This study done with the purpose of study the effect of performance care plan based on the Roy Adaptation Model on effects of fatigue in multiple sclerosis patients.

Methods: In this study, 80 patients with multiple sclerosis has selected the form of available, and randomly divided into two groups of 40 subjects were assigned to intervention and control. The data collected tool in this study was, fatigue effect scale that was completed, in both groups before and after the intervention. The intervention was consisted of 6 sessions, 2 general education sessions and 4 care programs based on maladaptive behavior sessions. Data analyzed with Spss software and descriptive- Inferential statistics.

Results: Before of intervention, the mean fatigue effects scores and that domain were not significantly different between the two groups. Mean of fatigue effects scores and that domain, decreased after-care programs based on the Roy adaptation model, in the intervention group, than the control group, that this reduction was statistically significant. (P < 0.001)

Conclusion: Implementation of the Roy Adaptation Model, reduce effects of fatigue in people with multiple sclerosis, therefore it is recommended that nurses use from this model to reduce effects of fatigue in patients.