Background: Caring for children with asthma creates a lot of tension for the parents. The present study was therefore conducted to investigate the effect of the family-centered empowerment model on the quality of life in parents of children with asthma.

  Methods: The present quasi-experimental study was conducted on 60 parents of children with asthma randomly divided into a case group and a control group. Seven sessions of training based on the empowerment model and after the assessment of the parents' needs were held for the case group over a period of four months. After the four months of training, the quality of life assessment instrument was once again completed by both the cases and the controls. Data were analyzed in SPSS/16 using statistical methods including the independent t-test, the paired t-test and Fisher's exact test.

  Result: There were no significant differences in the mean scores of knowledge, self-efficacy, self-esteem and quality of life between the case group and the control group before the intervention however, the differences between the two groups became significant after the intervention (P<0.001). In addition, the study revealed a significant difference in the mean scores of knowledge, self-efficacy, self-esteem and quality of life in parents of the case group after the intervention and then four months later (P<0.001).

  Conclusion: Due to the effectiveness of the family-centered empowerment model on the quality of life in parents of children with asthma, adopting this model is recommended in a larger scale.