Introduction & Objective: Chronic diseases with its prolonged period and disabilities have significant effect on the patients’ quality of life at all ages. Asthma  is one of these chronic  diseases , With an  inflammatory respiratory  system accompanied with significant morbidity  and , an  important  personal , social  and  economic impacts. This study aimed on assessment of quality of life in asthmatic patients of hospitalized at the educational hospitals of Karaj in Iran.   

Materials & Methods: A cross – sectional  study  was conducted with 400 Asthmatic  patients which were clients of  the educational  Karaj`s  hospitals during 2008-2009. Samples were  randomly selected and a questionnaire was used for  data  collection .The questionnaire  consisted of two section demographic characteristics, and six aspects of quality of life in    asthmatic patients (physical health, symptoms, daily activities, social, economic and emotional status ).

Results: The results showed that the major of patients(58.3%) stated a desirable  quality  of  life . The   assessment    of    relationship  between  quality of life and variables  such as age (p=0.00 )  ,  gender  from  aspect  of  daily  activities   (p=0.019 ) ,  married  status  (p=0.00) , number of child (p = 0.00)  , educational level (p= 0.00 ) , employed  (p=0.008) ,  duration  of disease (p=0.033) , hospitals  admission (p=0.003) , severity of  symptoms (p=0.00), previous Addiction from aspect  of  emotional  status(p=0.004).     .

Conclusion: The goal of  treatment  for chronic diseases are to diminish   the burden  on the patient and  to  prevent  or  slow  down  disease  progression  .  It  has  been recommended  to  evaluate  the  treatment  programs by  periodically quality of life assessment   in  Asthmatic  patients  as a part of comprehensive care .