Introduction: The purpose of this study was to investigate the cancer coping and its relationship with symptom management self-efficacy, perceived social support, uncertainty about life, and life orientation in Iranian breast cancer female survivors.
 Methods: This study was carried out through a descriptive-analytical cross-sectional method .The data were collected from 150 breast cancer survivors referred to educational and therapeutic centers in Urmia. The tools used to collect data were demographic characteristic questionnaire, cancer coping questionnaire, symptom management self-efficacy scale for breast cancer related to chemotherapy, Mishel uncertainty scale in illness, life orientation test perceived social support questionnaires during 2016. Data were analyzed using SPSS 20 and descriptive-analytical statistical tests.
 Results:  The symptom management self-efficacy, optimistic life orientation and perceived social support all correlated positively with cancer coping in women with breastcancer. Significant Negative correlation was identified between uncertainty and cancer coping (Significant at the 0.01 level (.). Results of stepwise multiple regression analysis demonstrated that 0.517% of the variance in cancer coping was elucidated by an integration of four predictors: perceived social support, symptom management self-efficacy, optimistic life orientation, and uncertainty.
Conclusion: The results of the study clarified that perceived social support, symptom management self-efficacy, uncertainty and optimistic life orientation have relationship with cancer coping among Iranian breast cancer female survivors. Thus, these variables should be taken into account while designing plans to promote cancer coping.