Introduction: Multiple Sclerosis threatens independence and ability of individuals in their family and society. The purpose of this study was to determine the effect of peer educational program on multiple sclerosis patient’s self-efficacy referred to Farshchian hospital and the Multiple Sclerosis Association of Hamadan City in 2015.

Methods: In this quasi-experimental study, 80 Patients with multiple sclerosis were selected with convenience sampling and randomly allocated to control and experimental groups. Four sessions, each 60 minutes, was performed twice a week. After one month after the last training session, self-questionnaires were completed by both experimental and control groups. Data were collected from both groups using the Sherer General Self-Efficacy Questionnaire. Data were analyzed with SPSS/16 using descriptive statistics, independent t and paired t tests.

Results: There was a significant difference between the mean scores of self-efficacy in the experimental group. The difference was not significant in the control group. There were no significant differences between the mean scores of self-efficacy of experimental and control groups before and after the intervention.

Conclusions: Peer education methods could increase the level of efficacy in patients with multiple sclerosis. This method could be used as a valuable strategy to improve the treatment and control of physical and psychological effects and increase the efficacy of the patient.