Background: Multiple sclerosis is a progressive disease of the central nervous system, that for a reason a variety of symptoms can cause destructive effects on quality of life. The aim of this study was to determine the effect of applying Orem’s self-care model on mental aspect of quality of life in patients with multiple sclerosis .

  Methods: In this quasi-experimental study, 74 patients with multiple sclerosis were selected by convenience sampling referred to the Hamadan MS Society office in 1393 and randomly divided into experimental and control groups. At first, demographic information and Multiple Sclerosis, Mental Quality of Life (MSMQOL-54) questionnaire were completed by experimental and control groups. 2-4 educational sessions for the experimental group were performed according to the patient needs. Two months after the self care performance by experimental group MSMQOL-54 questionnaires were completed by two groups. Data were analyzed by using Chi-Square, paired and independent t-tests.

  Result: In the experimental group, the mean of all mental aspect QOL was 57.2±20.5 before and 67.5±15.3 after intervention, that showed statistically significant difference before and after intervention (P<0.001). In the control group there was no significant difference in mental aspect QOL between before and after intervention .

  Conclusion: This study revealed that applying Orem’s Self-care Model could improve the mental aspect quality of life in patients with multiple sclerosis. It is recommended that this model be used to improve the mental aspect quality of life in these patients.