Background: Menopause is considered a critical stage of life and the most profound event among the middle-aged women. It is accompanied by not only physiological problems such as hot flashes, night sweats, anxiety, and sleep disorders, but also significant changes in quality of life. The present research sought to employ the PRECEDE model to investigate the determinants of quality of life among postmenopausal women in Bandar Abbas, Iran.

  Methods: The present research adopted a descriptive, analytical cross-sectional design. Cluster sampling was applied to select a total of 170 postmenopausal women from Bandar Abbas. A researcher-made questionnaire was used to collect data. Descriptive and inferential statistics were used to analyze the collected data in SPSS/16. P values less than 0.05 were considered significant.

  Result: The mean age of the participants was 57.00 ± 8.15 years. The mean score of quality of life among the studied postmenopausal women was 76.62 ± 27.05. There were significant relations between quality of life and enabling and reinforcing factors (p=0.048 and 0.026, respectively). Among all predisposing factors, attitude and perceived self-efficacy had significant relations with quality of life (p=0.002 and 0.045, respectively).

  Conclusion: Improving postmenopausal women’s quality of life requires the implementation of education and health programs by health workers, encouragement of other family members to contribute in health promotion programs, and development of social support networks to provide women with emotional support .