Volume 27, Issue 1 (3-2019)                   Avicenna J Nurs Midwifery Care 2019, 27(1): 11-17 | Back to browse issues page

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Borzouei S, Goodarzi M T, Biglari M, Nazari F, Shivapour Z. The Prevalence of Thyroid Disorders in Pregnant Women of Hamadan. Avicenna J Nurs Midwifery Care 2019; 27 (1) :11-17
URL: http://nmj.umsha.ac.ir/article-1-1908-en.html
1- Assistant Professor, Department of Endocrinology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , borzouei@umsha.ac.ir
2- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- General Physician, Hamadan University of Medical Sciences, Hamadan, Iran
4- MSc in Epidemiology, Hamadan university of medical sciences, Hamadan, Iran
Abstract:   (4457 Views)
Introduction: Different studies have demonstrated that maternal thyroid dysfunction during pregnancy is associated with adverse obstetrics and fetal outcomes. There is no international consensus regarding to use a guidelines for screening in high risk women. The aim of the present study was to determine prevalence of thyroid disorders in high and low risk pregnant women.
Methods: In a cross-sectional study during 2015-2016, from all pregnant women who had referred to Hamadan health center Lab for their first visit, a sample of 852 pregnant women were selected and assigned to low risk and high risk group. Thyroid tests and Anti TPO tests were carried out.
Results: Of 852 pregnant women, 26.5% had Subclinical hypothyroidism, 1.2% had overt hypothyroidism, 0.5% had overt hyperthyroidism and 0.2% had subclinical hyperthyroidism. 25.6% were in the high risk group and 74.4% in the low risk group and 37.4% of high risk group and 25% of the low risk population had thyroid disorders (P<0/001). 89% were Anti TPO negative and 11% were Anti TPO positive.
Conclusion: Hypothyroidism is common in pregnant women, and if screening is performed only in high-risk groups, 25% of pregnant women with subclinical and overt hypothyroidism will not  be detected explicitly. In addition, to determine the exact frequency of thyroid disorders, we need to look for newer and more effective criteria.
Persian Full-Text [PDF 459 kb]   (1142 Downloads)    
Type of Study: Original Research | Subject: Midwifery
Received: 2018/07/26 | Accepted: 2018/10/10 | Published: 2019/03/27

1. Van Raaij JA, Schonk C, Vermaat-Miedema S, Peek MM, Hautvast JA. Energy requirements of pregnancy in The Netherlands. The Lancet. 1987:953-5. [DOI:10.1016/S0140-6736(87)91431-0]
2. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine reviews. 1997;18(3):404-33. [DOI:10.1210/edrv.18.3.0300] [PMID]
3. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315-89. [DOI:10.1089/thy.2016.0457] [PMID]
4. Li C, Shan Z, Mao J, Wang W, Xie X, Zhou W, et al. Assessment of thyroid function during first-trimester pregnancy: what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? The Journal of Clinical Endocrinology & Metabolism. 2014;99(1):73-9. [DOI:10.1210/jc.2013-1674] [PMID]
5. Moon H-W, Chung H-J, Park C-M, Hur M, Yun Y-M. Establishment of trimester-specific reference intervals for thyroid hormones in Korean pregnant women. Annals of laboratory medicine. 2015;35(2):198-204. [DOI:10.3343/alm.2015.35.2.198] [PMID] [PMCID]
6. Glinoer D, Riahi M, Grün J, Kinthaert J. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. The Journal of Clinical Endocrinology & Metabolism. 1994;79(1):197-204. https://doi.org/10.1210/jc.79.1.197 [DOI:10.1210/jcem.79.1.8027226]
7. Wang C. The relationship between type 2 diabetes mellitus and related thyroid diseases. Journal of diabetes research. 2013. [DOI:10.1155/2013/390534] [PMID] [PMCID]
8. Lahoti SK, Toppo L. Subclinical hypothyroidism and pregnancy outcomes. Ann Int Med Den Res. 2015;1(3):324-6.
9. Korevaar TI, Schalekamp-Timmermans S, de Rijke YB, Visser WE, Visser W, de Muinck Keizer-Schrama SM, et al. Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: the generation R study. The Journal of Clinical Endocrinology & Metabolism. 2013; 98(11): 4382-4390. [DOI:10.1210/jc.2013-2855] [PMID]
10. Allan W, Haddow J, Palomaki G, Williams J, Mitchell M, Hermos R, et al. Maternal thyroid deficiency and pregnancy complications: implications for population screening. Journal of medical screening. 2000;7(3):127-30. [DOI:10.1136/jms.7.3.127] [PMID]
11. Casey BM, Dashe JS, Spong CY, McIntire DD, Leveno KJ, Cunningham GF. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstetrics & Gynecology. 2007;109(5):1129-35. [DOI:10.1097/01.AOG.0000262054.03531.24] [PMID]
12. Burch HB, Cooper DS. Management of Graves disease: a review. Jama. 2015;314(23):2544-54. [DOI:10.1001/jama.2015.16535] [PMID]
13. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081-125. [DOI:10.1089/thy.2011.0087] [PMID] [PMCID]
14. Pop VJ, de Vries E, van Baar AL, Waelkens J, De Rooy H, Horsten M, et al. Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development? The Journal of Clinical Endocrinology & Metabolism. 1995;80(12):3561-6. [DOI:10.1210/jcem.80.12.8530599] [PMID]
15. Taghavi M, Saghafi N, Shirin S. Outcome of thyroid dysfunction in pregnancy in Mashhad, Iran. 2009.
16. Naderi T, Honarvar Z, Bahrampor A, Yosefzadeh GH. The Prevalence of Hypothyroidism Based on Risk Factors in Pregnant Women Referred to Shahid Dadbin Clinic, Kerman, Iran. Journal of Kerman University of Medical Sciences. 2012 Jul 1;19(3):225-32.
17. Dehghani Zahedani M, Azinfar A, Mahouri K, Mehrdad S. The Identification of Related Risk Factors of Thyroid Disorder in an Iranian Pregnant Population. Iranian Journal of Endocrinology and Metabolism. 2010; 12 (4) :352-358
18. Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, et al. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? The Journal of Clinical Endocrinology & Metabolism. 2007;92(1):203-7. [DOI:10.1210/jc.2006-1748] [PMID]
19. Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. Bmj. 2011;342. [DOI:10.1136/bmj.d2616] [PMID] [PMCID]
20. De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism. 2012;97(8):2543-65. [DOI:10.1210/jc.2011-2803] [PMID]
21. Chang DL, Leung AM, Braverman LE, Pearce EN. Thyroid testing during pregnancy at an academic Boston Area Medical Center. The Journal of Clinical Endocrinology & Metabolism. 2011;96(9):E1452-E6. [DOI:10.1210/jc.2011-0360] [PMID] [PMCID]

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